How We'll Get Through The Coronavirus Debacle

News & Current Events Public News & Current Events
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As we prepare to enter “hell month” across the globe, when coronavirus infection and death totals will climb to peak intensity, today’s video looks at what we need to do to get out the other side of this pandemic as quickly and safely as possible.

First, we need to identify the best treatments asap and standardize around them. We’re starting to see promising contenders (e.g., early-on doses of hydroxychloroquine+azithromycin+zinc). Let’s separate the best from the rest and develop scalable protocols and deployment around them.

Second, we need to test the population for antibodies and put the recovered back to work NOW in critical positions (food delivery, first line of defense for health care, in-home care for the sick, etc)

Third, we need to get the low-risk folks back to work with effective PPE and self-protection practices, while keeping the at-risk safely isolated. In this way, we’ll get to herd immunity faster while reducing fatalities, restoring the economy, and protecting the health care system from being overwhelmed.

This is what we need to do. But will we do it?

Watching our current “leaders”, honestly, it will be a crap shoot. For every step forward, it seems we make a boneheaded policy response in return.

Which is why we all need to hope for the best but continue to plan for the worse.

In the interim, get started on your garden: https://www.peakprosperity.com/diygarden

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HYPERLINKS IN TODAY'S VIDEO

This is a companion discussion topic for the original entry at https://peakprosperity.com/how-well-get-through-the-coronavirus-debacle/

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I read the article about how COVID-19 might be a blood/iron issue, and it is intriguing. But I am troubled that no medical news outlet appears to be covering that angle. It sort of came out of nowhere, and went nowhere?? It was published on medium.com, which doesn’t give me any confidence at all.

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The article appears to have been removed from medium.com (for violation of rules?). But it is archived here: https://archive.is/ONUmi
 

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Putting the managers to shame…
https://www.cbc.ca/sports/ryan-reynolds-hayley-wickenheiser-medical-supplies-big-donations-1.5525345
PS: new Canadian social distancing rule = one hockey stick length. Sweet!!
Jan

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COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism
L. Wenzhong & L. Hualan
Abstract:

The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory infection caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. In this study, conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of certain proteins of the novel coronavirus. The results showed the ORF8 and surface glycoprotein could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10, and ORF3a proteins could coordinate attack the heme on the 1-beta chain of hemoglobin to dissociate the iron to form the porphyrin. The attack will cause less and less hemoglobin that can carry oxygen and carbon dioxide. The lung cells have extremely intense poisoning and inflammatory due to the inability to exchange carbon dioxide and oxygen frequently, which eventually results in ground-glass-like lung images. The mechanism also interfered with the normal heme anabolic pathway of the human body, is expected to result in human disease. According to the validation analysis of these finds, chloroquine could prevent orf1ab, ORF3a, and ORF10 to attack the heme to form the porphyrin, and inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of respiratory distress. Favipiravir could inhibit the envelope protein and ORF7a protein bind to porphyrin, prevent the virus from entering host cells, and catching free porphyrins. Because the novel coronavirus is dependent on porphyrins, it may originate from an ancient virus. Therefore, this research is of high value to contemporary biological experiments, disease prevention, and clinical treatment.
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The last couple nights I can’t send a fullscreen image to my Apple TV. Theatre mode is what’s available. It of course includes a large bar at the bottom to follow Coronavirus through the CDC.

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Hi Chris,
Thanks for all your work so far, I’ve been following your daily updates since late-January. Please check out New Zealand’s response so far. We implemented a pretty strict lockdown two weeks ago that seems to be now paying off. But on top of that, the government, knowing that major industries and businesses are going to be affected, initiated an economic relief package that got money to businesses, plus their affected employees, and individual contractors right from the beginning. No messing around. I have three friends who’s work has dried up since the Covid response measure who applied have for the relief package and their application were processed within days. The measures our government are implementing are helping the economy from falling apart while also stabilising the spread of Covid. It doesn’t seem many other countries are paying much attention to the work we’re doing, which is starting to pay off. I’d be interested to hear your thoughts whether we’re doing the right things health wise and economically.
Again, thanks for all your work so far.
Murray

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Keep it simple stupid. How many times I’ve heard that in becoming an engineer!
 
Yet intelligent people go to great means to explore all sorts of ideas. I guess money truly makes the world go around.
 
https://med.stanford.edu/covid19/research.html?fbclid=IwAR3fohGk46c3Qpnru47bB_PqYuY0U8uS4T4ioeUV7wfDZ0kYwslvci_38hQ#treatment-and-vaccination

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I read the article about how COVID-19 might be a blood/iron issue, and it is intriguing. But I am troubled that no medical news outlet appears to be covering that angle. It sort of came out of nowhere, and went nowhere?? It was published on medium.com, which doesn’t give me any confidence at all.
Welcome to the front lines of battling a brand new foe. Information is spotty, what we thought to be the case often turns out not to be the case, and we have to be willing to keep our minds wide open. I don't have great confidence in the theory either. I have zero clue how the virus proteins might become disassociated from the viral particulate structure and then cross the red blood cell membrane. My logical brain says "no way!" But then my observational brain has been wracked with the inconsistencies of the clinical progressions of patients and the weird comorbidity alignments. Why cancer and diabetes? Why obesity? Why hypertension? Why blood type A more than O? Why not renal disease? Then the progression of the disease...the bi-lateral nature seeming to nearly *always* be the presentation. The fact that ventilation offers so little in the way of healing support and possibly doing more damage. So let's start here. We don't yet have a good handle on this thing and what it's doing. Given that, we have to be ready to cast aside what we think we know and start at the beginning. What are the symptoms? What's the clinical data? How do we combine these into workable hypotheses that can be tested and rejected or bolstered? The hemoglobin hypothesis is tantalizing because it knits together so many of the dangly bits that didn't fit with the classical understanding of viral pneumonia but seem to align better with HAPE or carbon monoxide poisoning. Just kicking things around. Being curious. As a final note, I don't worry at all about someone's pedigree or presence or lack of certain degrees. I care about the logical progression of their ideas and whether they are considering multiple angles. Many of life's greatest advances have been brought about by people who specifically didn't have the necessary dogmatic orientation that prevented others from seeing things in a new way.
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Received via a chain email. Maybe you’ve gotten it too?
From a man named Chip strongly confirming my desire to never catch this thing, even a so-called “mild” case:

Roswell, GA I was released from WellStar North Fulton Hospital yesterday after nine days fighting viral covid-19 pneumonia - six days in the ICU and three on the medical floor. I thought I would share with you the top ten things I learned: On Wednesday, 3/11 I developed a dry cough and worked from home the rest of the week. I felt good and actually overdid it on Saturday running errands and doing things around the house. Lesson 1: Don't overdo it - f you have a cough, fever, shortness of breath, sore throat, loss of appetite, loss of sense of smell or other potential covid-19 symptoms, notify your doctor, rest and take over the counter medications that help your symptoms. From Sunday, 3/15 to Sunday, 3/22 my condition worsened. My cough persisted, I had very little energy, my sense of taste left me (food tasted like a mix of cardboard, sawdust and black mold) and toward the latter half of the week I started hearing a dry, crunchy sound in my chest. Lesson 2: Listen to your body - You know when something is wrong. Early in this week I should have contacted my doctor and gone in for an evaluation. I thought I was supposed to stay at home and not overwhelm the medical system. But if I had received medical treatment earlier - I may have avoided my stint in the hospital. By Sunday, 3/22 I was among the walking dead and Heidi was having no more of it. She loaded me in the car and we went to WellStar Urgent Care. During the check-in process I was impressed with how professional and attentive the staff were and how alarmed they were at my condition. They knew practically immediately I had pneumonia (remember the dry, crackly sound in my lungs?) and they measured my blood oxygenation level and said it was extremely low. They told us they could either call us an ambulance or we could drive, but that we were going to the WellStar North Fulton Hospital emergency room practically across the street. Heidi zoomed me over there and I was whisked away to emergency. That was the last I saw of Heidi for nine days. While in the emergency room I sort of went into slow-mo mode. I could see how concerned the emergency room staff were and the thought occurred to me that I was circling the drain. I was so weak and tired the realization didn't scare or alarm me - it was just an observation. I snapped out of it when Dr. Tony said my situation was very serious and that they were going to put me on oxygen. If my blood oxygen levels did not improve quickly, they were going to incubate me and put me on a respirator. Lesson 3: Push for the least invasive treatment option - This is the hardest lesson to describe yet the most important of my experience. I think if I had relinquished control of my recovery to a machine - I would have been in the ICU longer. I don't know this - I just feel it. I asked the doctor to give me a chance with the oxygen and focused all my energy on breathing as deeply as my crackly lungs would allow. Over time, my blood 02 levels improved - so much so that they actually switched me over to just an oxygen tube that fit in my nose. During the early part of my stay in the ICU, it became obvious that for the foreseeable future my life would suck. Lesson 4: Embrace the suck - At this point it seemed everyone wanted a piece of me. Technicians getting vital signs, blood draws, x-rays, the works. If you ever get in this situation - the suck is what is going to save you. This is where the medical team is getting the vital information they need to help you. If they want to draw blood every morning at 3:15 (they did) you smile at them and thank them when they're done. Same with the folks that come at awkward hours to get your vital signs - which tells them how you're progressing and gives them early warning if something is going wrong. The belly shot at 5:00 pm to thin your blood? Tomorrow let's do cocktails with that! You are always glad to see them and hope they come again soon. The staff also tested me for Flu A/Flu B which entails inserting a bristly feeling wire into your sinuses and pulling it back out. They also tested for covid-19 (winner) which involved inserting a bristly feeling wire into my sinuses, but then taking a tour of the inside of my head by twirling the wire around. Embrace this and just live in the moment while they do it (which happens automatically since you will not be thinking of anything else during the "swabbing"). By Tuesday, 3/24 things had improved enough that I knew I was going to be ok - I just didn't know how long it was going to take me to get out of the ICU. The staff gave me some devices to help me with my breathing - one for inhaling and one for exhaling. They set goals for me each day - which mainly consisted of getting off the supplemental oxygen and working with my breathing devices. Lesson 5: Take what is offered / Do what you are told - At this point my appetite was back and I was better able to get out of bed and take care of myself. I figured the staff knew what they were doing (they did - I love them) so I decided I would accept whatever they gave me and do whatever they wanted me to do. I ate everything they brought me, drank water almost continuously, used the breathing devices on every commercial break or every 10 minutes or so if the TV was off (really weird watching the news anchors discuss the coronavirus while you are in the ICU with it). I think getting with the program early really helped my recovery. Also by Tuesday-ish , I was also getting to know the medical staff. They operate as a team and are very professional. I knew by watching them enter the room that they had strict protocols on personal protective equipment (PPE) and how to interact with me. Lesson 6: Join the team - Since the nurses and techs had to come in fairly regularly to check on me, bring meals, etc - we quickly reached an understanding on how we could help each other. In order to minimize the amount of PPE they had to use, I asked them to bring two cups of ice water every time they came in. This would last me four hours or so and meant they wouldn't have to come in as often. Cooperate with your team - they are nice people! As I began to feel better on Tuesday and Wednesday I started asking whether there were other covid patients in the ICU. The nurse said my whole side of the ICU was covid. I asked her how they were doing and that's when I learned that despite the medical team's best efforts, considerable skill and medical technology - their patients were dying from the virus. Lesson 7: Be kind to your staff and be understanding of what they are going through - Imagine a job where you report for your shift and people are in various stages of dying. I began talking to the people that came in my room and asked how they were doing, thanked them for their help and praised them for being willing to endanger themselves to help their patients. Everyone likes to feel appreciated - and your staff needs to hear it. If you know a medical person that is dealing with covid patients - please reach out to them and let them know you are thinking of them and admire what they are doing. We need them! Each day I was reducing my need for supplemental oxygen and was getting close to my goal of eliminating it completely. Soon we started talking about me leaving the ICU and going to a regular room on the medical floor. This happened on Friday, 3/27. Even though I was still on supplemental o2, I was given a transfer to the medical floor. Nurse Katie came to help me move and there was also an assistant with a wheelchair. Katie asked me if I wanted to walk to the new room and I told her I would love to stretch my legs. As we were leaving, one of the key ICU doctors passed me and stopped Katie and the wheelchair lady to speak with them. He was speaking in low tones and at first I was worried he was getting on to them because I wasn't in the wheelchair. But then I heard Katie tell him that he should tell me what he just said. The doctor came up to me and said that no one with the level of infection I had was still alive - and that of all the covid patients they have treated, none had walked out of the ICU. I told him I was a testament to the great care I had received from him and his staff and North Fulton Hospital. My walk from the ICU to the medical floor was one of the best of my life! Lesson 8: Be thankful you are alive - no explanation needed. When I got to my new room, I was shocked it had a window. In the ICU and in my new room, they had to make the room have negative pressure so when the door opened air came in instead of blowing the covid virus out into the hall. To do this they took out a window, added strong cardboard and rigged it to have a blower shooting air out of the room to the outside. Since the ICU room only had one window, I had not seen the sky in almost a week. The medical floor rooms had two windows and I just sat down and stared out of the one that remained (there was even a hawk flying around). I was overwhelmed from just being able to see outside. I felt like a prisoner who had just been taken out of the hole and given a pardon forgiving my death sentence. It was a powerful moment. Lesson 9: Take nothing for granted - There is still a lot of great things happening all around us - time with our families, texts with friends, walking your dog, drinking water with ice in it, looking at the sky. Every little moment is precious - enjoy it. While on the medical floor I finally got off the supplemental oxygen and had to go through another round of medications before I could finally go home on Monday, 3/30. What a sweet ride! Heidi picked me up and took me home. Cruelly, I cannot be near her as I will still be contagious for about a week and have to wear a mask whenever I pass through a common area in our house. I catch a glimpse of her now and then - she's a babe! Lesson 10: Give back - I do not know exactly how I will exact revenge on covid-19, but I will get it. For starters, I have written this account of my experience so that you know what to expect in case you contract the virus, to encourage you to do everything the CDC and other experts tell you to do to avoid it and maybe to scare straight those of you that have become complacent thinking this will not happen to you. It can - and you do not want anything to do with covid-19 and you sure as hell don't want to be responsible for giving it to someone else. I have also heard that over the next few weeks I will begin to develop anti-bodies to the virus. I have also heard that there are studies underway to see if these anti-bodies can be used to treat those that have contracted covid-19. I would love it if my anti-bodies could kill this damn virus in others. THAT would be sweet, sweet revenge. Until I see you again - wash your hands, make the best of these crazy times and take care of yourselves. Love, Chip
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Before the US joined WWII, Winston Churchill was quoted as saying, “You can always count on Americans to do the right thing, after they have tried everything else.”
I’ve thought of this quote several times during the Covid-19 pandemic.
The thing is, we are not the same country that existed in 1940. I’m unconvinced that Churchill’s quote still applies to the majority

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Found a picture from an ER doc’s group discussing this topic. This would go with the attack on hemoglobin viewpoint by several non-structural proteins made by COVID during infection of human cells.

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https://zenodo.org/record/3698160#.Xo3DXCWIaEc
Dr. Lawrence Broxmeyer has from the start had a different view of the virus.
 

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Here it is! Perfectly well done. Inspiring. Awesome. These folks have hit it out of the park.
Here’s your step by step pattern/instructions for making your own ~N95 masks.
https://cdn.shopify.com/s/files/1/0050/2474/3524/files/Suay_Mask_Pattern_2020.pdf?v=1586309614

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Looks like hydroxychloroquine along with Zinc and an antibiotic works. If it works, why do we need to see if it works by testing? Do we believe it works or don’t we? Let’s assume that it does work. So put on a mask, go to work, expose yourself to a small infection, get sick, see your doctor, get some pills and go back to work. Now you are immune. Treat this like we treat the common cold. We will eventually all get the virus. Do you know anyone who hasn’t had a cold? Skip all the testing, all the new hospitals, ventilators, etc. and make this simple. Produce lots of masks and pills. I understand that TPTB don’t want this to happen. The people need to push this.

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I never expected backordered garden seeds this year.

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I think the answer to your question is: We don’t decide.
That’s why in France we have had the Yellow Jackets.
Maybe we have to question Their motives - like Why are They putting forward Kamakazi solutions?
If 99% of people infected became well enough after 5 days to work again and infect no one - then no ventilators, ICU.
Ah but the Lupus patients! Please show us how many Lupus patients have become infected. Then tell us it didn’t work for them.

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Hearing some discussion today about how the SARS- COV2 virus may have an unsuspected mechanism which is causing the refractory hypoxia and subsequent lung damage in patients. Heres a link to that story in the web
Covid-19 had us all fooled, but now we might have finally found its secret.
https://web.archive.org/web/20200405061401/https://medium.com/@agaiziunas/covid-19-had-us-all-fooled-but-now-we-might-have-finally-found-its-secret-91182386efcb
Did a little digging and found this paper from China that proposes the mechanism.
https://s3-eu-west-1.amazonaws.com/itempdf74155353254prod/11938173/COVID-19__Attacks_the_1-Beta_Chain_of_Hemoglobin_and_Captures_the_Porphyrin_to_Inhibit_Human_Heme_Metabolism_v5.pdf
I’m just a clinician but is seems to make some sense. Also gives a proposed mechanism of how Chloroquine is helpful.

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buy a two year supply of the staples. Put one years worth in your solar chest freezer. Always, ALWAYS, buy a year in advance.
a farm boy whose dad died young and was raised by his Grandparents who were married in 1917. They were and we are fairly resilient. We could ease back into the 18th-19 th without too much pain. The farm and community does need a miller and a tanner/leathersmith.

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Give thanks for your President
https://sputniknews.com/india/202004081078879491-trump-does-u-turn-praises-india-for-supplying-game-change-drug-to-fight-covid-19/